![]() Tuberculosis (TB) is a disease of global concern due in part to increasingly antibiotic-resistant bacteria. (2015) Strategy for identifying repurposed drugs for the treatment of cerebral cavernous malformation. The company is using a similar approach to identify compounds to target other diseases.įor more details: Gibson CC et al. ![]() This led to the launching of Recursion Pharmaceuticals, which is pursuing a clinical trial for a compound to treat CCM, which has no currently approved therapy. They then identified known drugs that could reverse the phenotype and demonstrated efficacy in a mouse model of CCM disease. Researchers at the University of Utah used CellProfiler to identify image-based phenotypes associated with a monogenic rare disease, the hereditary stroke syndrome cerebral cavernous malformation (CCM). (2015) Two-pore channels control Ebola virus host cell entry and are drug targets for disease treatment. CellProfiler was used to identify therapeutic targets within host human macrophages capable of halting infection by inhibiting viral uptake via cell surface proteins and endosomal trafficking.įor more details: Sakurai Y et al. The 2014 outbreak of the Ebola virus in West Africa has claimed the lives of over 8,600 people worldwide the disease currently has no approved cure or vaccine. The Lancet Haematology, 4 (12), e595-e606: paper (2017) Image-based ex-vivo drug screening for patients with aggressive haematological malignancies: interim results from a single-arm, open-labeled, pilot study. Involving a large collaboration across Vienna and Switzerland, this is the first precision medicine trial in leukemia/lymphoma that used microscopy-based functional screening.įor more details: Snijder B et al. Cells were then treated with a panel of approved drugs and each patient was given one or more of the drugs that was most effective at killing their particular cancer cells, as judged by CellProfiler analysis of cell images. Cancer cells were collected from patients whose aggressive cancers had relapsed after conventional treatments. Please let us know if you are aware of others! See also: citationsĬellProfiler is being used to guide treatment decisions in a clinical trial for various types of leukemias and lymphomas. Here we highlight instances that have come to our attention. In some cases, discoveries made using CellProfiler have even led to planning clinical trials in humans, which could directly improve patient outcomes. For example, CellProfiler has been used to identify several small molecules that are effective in treating particular diseases in mouse models. ![]() Our CellProfiler software has yielded discoveries in several translational projects, some of which have had a direct impact on the treatment of disease.
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